The status of women in India has been subjected to many great changes over the past few millennia. Although the status of women has brought desirable changes in their status, self-protection (SP) for them is poor. According to a report by Thompson Reuters (2016), India is ranked as the fourth dangerous country in the world for women, and India was also noted as the worst country for women among the G20 countries. Considering the burden, the investigators have taken a small step to create awareness on self-protection among student nurses. The objective of the study was to determine the effectiveness of self-defense training program. A pre-experimental one-group pretest and posttest design was adopted by the present study. The study was conducted at Billroth College of Nursing, Chennai. The sample size was 30. A structured knowledge questionnaire on self-protection that consists of 30 items was used to identify the knowledge on self-protection. The analysis revealed that the level of knowledge on self-protection in pretest 20 (74%) had a poor knowledge, 8 (26%) had a moderate knowledge, none of them had a good knowledge; but in posttest, none of them had a poor knowledge, 10 (33%) had a moderate knowledge, and 20 (67%) had a good knowledge. The findings revealed that in pretest, mean score was 37.7 with standard deviation (SD) of 10.59, but in posttest, mean score was 91.2 with the SD of 10.56. The t value was t = 11.104 that showed a significance at the level of p < 0.05.